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Encorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer

By reducing inflammation, fasting helps the body retain and even increase its supplies

The 12mg cohort achieved the highest mean body weight reduction at -24.2% exceeding all published results for semaglutide (approximately -16% in the STEP trials) and tirzepatide (approximately -22.5% in SURMOUNT-1) at their respective maximum doses

GSH depletion-dependent cell death was prevented by selective ferroptosis inhibitors (8 M Fer-1 and 600 nM Lip-1), iron chelator DFO (80 M), as well as autophagic inhibitors Baf-A1 (75 nM) and 3-MA (10 mM)

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For example, it is not clear whether intestinal microbiota can form SFN conjugates such as SFN-GSH or SFN-NAC